Improved process for the manufacture of mirtazapine

Details Improved process for the manufacture of mirtazapine Improved process for the manufacture of mirtazapine

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2572831

Improved process for manufacturing mirtazapine. A process is described for preparing mirtazapine starting from a compound of formula (II), which is subjected to a ring cyclization, obtaining mirtazapine for pharmaceutical use in crystalline and anhydrous form.

L'invention porte sur un procédé amélioré de fabrication de mirtazapine. Le procédé de l'invention permet de préparer la mirtazapine à partir d'un composé de la formule (II), qui est soumis à une cyclisation menant à l'obtention d'une mirtazapine à usage pharmaceutique sous une forme cristalline et anhydre.

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