Improved process for the preparation of copolymer-1

Details Improved process for the preparation of copolymer-1 Improved process for the preparation of copolymer-1

C - Chemistry, Metallurgy

08

G

C08G 69/04 (2006.01) C08G 69/10 (2006.01) C08G 69/48 (2006.01) C07K 1/06 (2006.01)

Patent

CA 2656573

The presently disclosed subject matter provides a novel method for preparing copolymer- 1. In one embodiment, a mixture of N-carboxyanhydrides (NCAs) comprising alanine, protected-glutamic acid, protected lysine, and tyrosine, and wherein glutamic acid includes a benzyl or methoxy protecting group and lysine includes a cyclic imide or Boc protecting group are treated with a polymerization initiator to initiate polymerization of the mixture of N-carboxyanhydrides and to thereby synthesize a protected copolymer- 1. The protected copolymer- 1 can then be treated with deprotecting groups and/or depolymerized to obtain a copolymer- 1 having a desired molecular weight.

La présente invention concerne un procédé innovant de préparation de copolymère-1. Selon un mode de réalisation, un mélange d'anhydrides N-carboxyliques (N-carboxyanhydrides; NCA), comprenant de l'alanine, de l'acide glutamique protégé, de la lysine protégée et de la tyrosine et dans lequel l'acide glutamique inclut un groupe protecteur benzyle ou méthoxy et la lysine inclut un groupe protecteur imide cyclique ou Boc, est traité avec un initiateur de polymérisation pour déclencher la polymérisation du mélange d'anhydrides N-carboxyliques et pour synthétiser ainsi un copolymère-1 protégé. Le copolymère-1 protégé peut ensuite être traité par des groupes dé-protecteurs et/ou il peut être dé-polymérisé pour donner un copolymère-1 ayant la masse moléculaire cherchée.

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