Improved process for the preparation of ezetimibe

Details Improved process for the preparation of ezetimibe Improved process for the preparation of ezetimibe

C - Chemistry, Metallurgy

07

D

C07D 205/08 (2006.01)

Patent

CA 2613239

The present invention relates to a cost effective and industrially advantageous process for the preparation of (3R,4S)-l-(4-Fluorophenyl)-3-[3(S)- 3-(4-fluorophenyl)-3 - hydroxypropyl)]-4-(4-hydroxy.rho.henyl)-2-azetidinone, referred to here as Ezetimibe, it is represented as formula (1).

La présente invention concerne un procédé avantageux du point industriel et peu coûteux pour la préparation de (3R,4S)-l-(4-fluorophényle)-3-[3(S)-3-(4-fluorophényle)-3-hydroxypropyle)]-4-(4-hydroxy.rho.hényle)-2-azétidinone, dénommée ici ézétimibe, représentée par la formule (1).

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