A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01) C07F 9/02 (2006.01)
Patent
CA 2573396
Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
L'invention concerne de nouvelles voies de synthèse, qui sont hautement applicables dans la préparation industrielle de phospholipides oxydés avantageux sur le plan pharmaceutique. Plus particulièrement, cette invention concerne de nouveaux procédés permettant de préparer de façon efficace des composés à structure glycérolique et une ou plusieurs fractions oxydées rattachées à ladite structure, dépourvues de chromatographie sur colonne. L'invention concerne également de nouveaux procédés destinés à introduire des fractions contenant du phosphore telles que des fractions de phosphate dans les composés à structure glycérolique et des intermédiaires formés à partir de ces fractions.
Halperin Gideon
Kovalevski-Ishai Eti
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Vascular Biogenics Ltd.
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