C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 213/02 (2006.01) C07C 215/64 (2006.01) C07C 217/74 (2006.01)
Patent
CA 2674034
The present invention relates to an improved process for the preparation of essentially pure Venlafaxine Hydrochloride. Particularly, the process for the preparation of Venlafaxine Hydrochloride comprises the following steps: i) Preparation of l-[Cyano-l- (4-methoxyphenyl) methyl] cyclohexanol, ii) Preparation of crude Venlafaxine Hydrochloride by reduction of l-[Cyano-l-(4-methoxyphenyl) methyl] cyclohexanol with Alkali metal borohydride and Lewis acid and subsequent conversion to Venalfaxine hydrochloride with formic acid and paraformaldehyde and finally iii) Purification of crude Venlafaxine Hydrochloride.
La présente invention a pour objet un procédé amélioré de préparation de chlorhydrate de venlafaxine essentiellement pur. Ce procédé de préparation de chlorhydrate de venlafaxine comprend particulièrement les étapes suivantes : i) Préparation de l-[cyano-l-(4-méthoxyphényl)-méthyl]cyclohexanol, ii) Préparation de chlorhydrate de venlafaxine brut par réduction du l-[cyano-l-(4-méthoxyphényl)-méthyl]cyclohexanol avec un borohydrure de métal alcalin et un acide de Lewis puis une conversion en chlorhydrate de venlafaxine avec de l'acide formique et du paraformaldéhyde et finalement iii) Purification du chlorhydrate de venlafaxine pur.
Georgopoulou Ioanna
Koftis Theocharis
Panagiotidis Theodoros
Soni Rohit Ravikant
Dimock Stratton Llp
Pharmathen S.a.
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