C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 503/00 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2337072
A process for the production of an amine salt of clavulanic acid and the conversion thereof into a pharmaceutically acceptable salt or ester thereof has been provided. During the crystallisation phase of the amine salt of clavulanic acid either a clavulanic acid containing solution, optionally with a cosolvent, is added to the amine or both reactants are added together to a cristallisation vessel. Also the application of a temperature profile (decreasing in time), profile of speed of addition (increasing in time) and a profile of the ratio amine/clavulanic acid (increasing in time) for this cristallisation process has been provided for.
La présente invention concerne un procédé de préparation d'un sel aminé d'acide clavulanique et sa transformation en un sel ou un ester pharmaceutiquement acceptable. Pendant la phase de cristallisation du sel aminé d'acide clavulanique, on ajoute soit une solution renfermant de l'acide clavulanique au sel aminé, éventuellement avec un co-solvant, soit les deux réactifs ensemble dans une cuve de cristallisation. L'invention concerne également l'application au processus de cristallisation d'un profil de température (à diminution dans le temps), d'un profil de vitesse d'adjonction (à augmentation dans le temps) et d'un profil du rapport sel aminé/acide clavulanique (à augmentation dans le temps).
Kerkhof Pieter Theodorus
Lefferts Ageeth Geertruida
Dsm N.v.
Osler Hoskin & Harcourt Llp
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