Improved process for the production of an n-acyl derivative...

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 9/24 (2006.01)

Patent

CA 2280381

The present invention relates to an improved process for the preparation of an acyl derivative of O,S-dialkyl phosphoroamidothioate by reacting an O,S-dialkyl phosphoroamidothioate with an acylating agent in the presence of an acid, wherein the improvement resides in adding a C4 to C8 aliphatic alcohol, following completion of the acylation reaction, to the mixture of the O,S-dialkyl phosphoroamidothioate, the acylating agent and the acid. In an embodiment of the present invention, the acylation reaction is conducted in the absence of a solvent. The aliphatic alcohol is easily recovered and can be reused in a subsequent acylation reaction.

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