Improved process for the production of daptomycin

Details Improved process for the production of daptomycin Improved process for the production of daptomycin

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) C07K 11/02 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2674257

The present invention relates to an improved process for the production of Daptomycin by fermentation with Streptomyces roseosporus, in the presence of n-decanal or Cuphea oil as sources of the n-decanoyl side chain. These reagents allow to reduce toxicity effects on the bacteria and to avoid the use of solvents in the feeding solution.

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