Improved process for the production of nucleotide sugars

Details Improved process for the production of nucleotide sugars Improved process for the production of nucleotide sugars

C - Chemistry, Metallurgy

07

H

C07H 19/10 (2006.01) C07H 1/06 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2690611

The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly(propylene glycol)) moieties. A typical process of the invention includes anion exchange chromatography followed by an ultrafiltration procedure, such as tangential flow filtration. The process of the invention provides modified nucleotide sugars in unexpectedly high purity and high overall yields.

L'invention propose des procédés (par exemple des procédés à grande échelle) pour la production de sucres de nucléotide qui sont modifiés avec un groupe de modification polymère, tel que des fractions de poly(oxyde d'alkylène) (par exemple le poly(éthylène glycol) ou le poly(propylène glycol)). Un procédé typique de l'invention comprend la chromatographie d'échange d'anion suivie par une procédure d'ultra filtration, telle que la filtration à flux tangentiel. Le procédé de l'invention fournit des sucres de nucléotide modifiés en une pureté élevée et des rendements globaux élevés inattendus.

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