Improved process for the synthesis of...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/78 (2006.01) C07D 213/80 (2006.01)

Patent

CA 2141046

An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy- 5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluor- onicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5- fluoronicotinic acid.

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