Improved processes for the preparation of d-chiro-inositol

Details Improved processes for the preparation of d-chiro-inositol Improved processes for the preparation of d-chiro-inositol

C - Chemistry, Metallurgy

07

C

C07C 35/16 (2006.01) C07C 29/10 (2006.01)

Patent

CA 2203680

A method for the preparation D-chiro-inositol (I) from kasugamycin (II), comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D- chiro-inositol product.

L'invention porte sur un procédé de préparation de D-chiro-inositol (I) à partir de kasugamycine (II), qui consiste à: a) faire réagir de la kasugamycine avec un agent acétylant afin d'obtenir un intermédiaire non-raffiné d'hexa-acétate; b), purifier celui-ci en vue d'obtenir un intermédiaire d'hexa-acétate purifié; c), désacétyler cet intermédiaire purifié afin d'obtenir du D-chiro-inositol et, d) isoler ce dernier. Le procédé permet une production rentable et sur grande échelle de D-chiro-inositol sans qu'il soit nécessaire de recourir à une purification en chromatographie exhaustive du produit final, le D-chiro-inositol.

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