Improved processes for the synthesis of olanzapine

Details Improved processes for the synthesis of olanzapine Improved processes for the synthesis of olanzapine

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01)

Patent

CA 2593407

There is provided a process for the preparation of olanzapine comprising: i) reacting 4-amino-2-methyl-10H-thieno-[2,3-b][1,5]benzodiazepine and N-methylpiperazine in a C1 to C4 alcoholic solvent or mixture thereof at suitable temperature and for a suitable time, ii) cooling the reaction mixture, and iii) isolating the precipitated olanzapine.

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