Improved processing of recombinant human g-csf

Details Improved processing of recombinant human g-csf Improved processing of recombinant human g-csf

C - Chemistry, Metallurgy

07

K

C07K 14/535 (2006.01)

Patent

CA 2738116

A G-CSF precursor comprising a signal peptide and a G-CSF peptide, wherein the signal peptide has the sequence of the human wild-type signal peptide of the human G-CSF/b molecule with at least one of the following mutations: - -deletion of G1u29, - insertion of G1u26, - substitution Lys11 Leu, -- substitution His21Phe, and - substitution Glu28Leu.

La présente invention concerne un précurseur du G-CSF comprenant un peptide de signal et un peptide G-CSF, ledit peptide de signal possédant la séquence du peptide de signal de type sauvage humain de la molécule G-CSF/b humaine avec au moins l'une des mutations suivantes : suppression de Glu29; insertion de Glu26; substitution de Lys11 Leu; substitution de His21Phe; et substitution de Glu28Leu.

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