C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/113 (2006.01)
Patent
CA 2434045
The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, "stepped" depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
L'invention concerne des procédés améliorés permettant de désagréger des agrégats de protéines, et de replier des protéines dénaturées, par le biais d'une haute pression. En particulier, le procédé fait appel à l'agitation, à une haute température, à une dépressurisation <= par étape >=, à une dialyse et à une dilution sous pression, afin d'augmenter la vitesse et l'ampleur de la dissolution de l'agrégat et du repliement des protéines.
Carpenter John F.
Randolph Theodore W.
St. John Richard J.
Webb Jonathan N.
Barofold Inc.
Goudreau Gage Dubuc
The Regents Of The University Of Colorado A. Body Corporate
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