Improved protein secretion in eukaryotic cells

Details Improved protein secretion in eukaryotic cells Improved protein secretion in eukaryotic cells

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 9/24 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2518580

The present invention relates to the use of a glucosidase II mutation to increase protein secretion in eukaryotic cells. The present invention relates further to the use of an eukaryotic cells, comprising a mutant glucosidase II gene, possibly in combination with the expression of a recombinant .alpha.-1,2 mannosidase gene and/or a recombinant N-acetylglucosaminyl-transferase gone, as a host for protein secretion.

L'invention concerne l'utilisation d'une mutation de la glucosidase II pour augmenter la sécrétion de protéines dans des cellules eucaryotes. L'invention porte également sur l'utilisation de cellules eucaryotes comportant un gène de glucosidase II muté, éventuellement combinées à l'expression d'un gène d'.alpha.-1,2-mannosidase et/ou d'un gène de N-acétylglucosaminyl-transférase recombiné, en tant qu'hôte pour la sécrétion de protéines.

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