Improved reagents for a cannabinoid immunoassay

Details Improved reagents for a cannabinoid immunoassay Improved reagents for a cannabinoid immunoassay

C - Chemistry, Metallurgy

07

K

C07K 16/16 (2006.01) A61K 39/385 (2006.01) C07D 311/58 (2006.01) C07D 405/12 (2006.01) C07K 16/44 (2006.01) G01N 33/531 (2006.01) G01N 33/543 (2006.01) G01N 33/94 (2006.01) C07D 311/80 (2006.01)

Patent

CA 2172663

The present invention provides: -novel benzpyran derivatives of formula (see formula I) where R1 is a linear or branched alkyl group having from 1 to 9 carbon atoms; R2 and R3 are independently selected from linear or branched lower alkyl which can be substituted by one or more of the following functional groups -OH, -COR4, -NR5R6, -SH, -C(=NH)-OR7, -CHO, or =O, provided that at least one of R2 or R3 is substituted by at least one of the above-described functional groups; R4 is -OH or a leaving group; R5 and R6 are independently selected from the group consisting of H, and linear or branched lower alkyl; R7 is linear or branched lower alkyl; and a, b, and c are independently single or double bonds, provided that when b is a double bond, then a and c are not double bonds, - novel antibodies produced using those benzopyran derivatives, methods for producing these antibodies and immunoassays using the latter for the detection of tetrahydrocannabinol metabolites in blood or urine samples.

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