Improved recombinant human interferon-beta-1b polypeptides

Details Improved recombinant human interferon-beta-1b polypeptides Improved recombinant human interferon-beta-1b polypeptides

A - Human Necessities

61

K

A61K 38/21 (2006.01) C07K 14/565 (2006.01)

Patent

CA 2528514

The present invention relates to recombinant human interferon-beta-1b (~IFN- beta-1b~) polypeptides, or fragments analogs, derivatives, or variants thereof, having an improved specific activity. The present invention also relates to pharmaceutical compositions comprising such IFN-beta-1b polypeptides. or fragments, analogs, derivatives, or variants therof, useful for treating multiples sclerosis. The present invention further relates to methods of producing such IFN-beta-1b compositions.

La présente invention a trait à des polypeptides de l'interféron-bêta-1b ( IFN-.beta.-1b ) humains recombinants, ou leurs fragments, analogues, dérivés, ou variants, présentant une activité spécifique améliorée. La présente invention a également trait à des compositions pharmaceutiques comportant de tels polypeptides de IFN-.beta.-1b, ou leurs fragments, analogues, dérivés, ou variants, utiles pour le traitement de la sclérose en plaques. La présente invention a trait en outre à des procédés de production de telles compositions de IFN-.beta.-1b.

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