A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/14 (2006.01) A01N 25/08 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61L 26/00 (2006.01) C05G 3/00 (2006.01)
Patent
CA 2108680
- 55 - IMPROVED RETARD SYSTEMS FOR THE SUSTAINED RELEASE OF MEDICINAL AND/OR BIOLOGICAL VALUABLE MATERIALS FROM A DEPOT CARRIER MATERIAL Abstract of the Disclosure The invention, in a first embodiment, relates to the use of free radical-reactive cross-linker components based on olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof for modifying depot materials, and especially retard systems, which contain medicinal and/or biological valuable materials in admixture with a carrier material in a sustained release of the active substance(s) in practical application. The cross-linkers are present as polymer compounds in the application form of the retard system and may be provided in the retard system or depot material to be applied in a largely homogeneous as well as in a non-uniform distribution. The invention further relates to retard systems which contain medicinal and/or biological valuable materials and have been based on oligomer and/or polymer compounds of lower hydroxycarboxylic acids as carrier materials providing a sustained release of the active substance, the invention being characterized in that said retard systems and/or depot materials have been modified with polymer compounds prepared from olefinically unsaturated esters of lower hydroxycarb- oxylic acids and/or oligomers thereof.
Lehmann Rudolf
Ritter Wolfgang
Sorg Rainer
Borden Ladner Gervais Llp
Merck Patent Gmbh
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