C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) C12N 1/14 (2006.01) C12N 1/16 (2006.01) C12N 1/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2402111
The present invention relates to an improved reverse n-hybrid screening method for identifying antagonists or inhibitors of biological interactions, wherein multiple genes are employed to distinguish antagonists or inhibitors of one interaction from those antagonists or inhibitors of other interactions, particularly where each of said interactions involves one or more common interacting partners. A further aspect of the invention provides novel expression vectors for performing the inventive method, particularly in high throughput screens.
La présente invention concerne une méthode de criblage inverse à n hybrides améliorée permettant d'identifier des antagonistes ou inhibiteurs d'interactions biologiques, dans laquelle sont utilisés de multiples gènes pour distinguer les antagonistes ou inhibiteurs d'une interaction des antagonistes ou inhibiteurs d'autres interactions, en particulier lorsque chacune desdites interactions implique un ou plusieurs partenaires d'interaction communs. L'invention concerne également de nouveaux vecteurs d'expression permettant de mettre en oeuvre la méthode de l'invention, en particulier dans les criblages à haute capacité.
Golemis Erica
Hopkins Richard
Serebriiskii Ilya
Watt Paul Michael
Phylogica Limited
Smart & Biggar
Tvw Telethon Institute For Child Health Research
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