Improved ricin-like toxins for treatment of cancer

Details Improved ricin-like toxins for treatment of cancer Improved ricin-like toxins for treatment of cancer

C - Chemistry, Metallurgy

12

N

C12N 15/29 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C07K 14/415 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2386237

The present invention provides a protein having chain of a ricin-like toxin, a B chain of a ricin-like toxin and a novel heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a specific protease such as those found in inflammatory cells and cancer cells. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying cells having a specific protease, such as cancer cells or inflammatory cells utilizing the nucleic acid molecules and proteins of the invention and pharmaceutical compositions for treating human inflammation and cancer.

L'invention concerne une protéine qui comprend une chaîne A d'une toxine de type ricin, une chaîne B d'une toxine de type ricin, ainsi qu'une séquence d'acide aminé de liaison hétérologue qui relie les chaînes A et B. La séquence de liaison contient un site de reconnaissance de clivage pour une protéase spécifique telle que celle que l'on trouve dans des cellules inflammatoires et cancéreuses. L'invention concerne également une molécule d'acide nucléique codant la protéine, ainsi que des vecteurs d'expression renfermant ladite molécule. Elle concerne en outre un procédé qui permet d'inhiber ou de détruire des cellules comportant une protéase spécifique, par exemple des cellules cancéreuses ou inflammatoires, à l'aide des molécules d'acide nucléique et desdites protéines. L'invention concerne enfin des compositions pharmaceutiques destinées au traitement d'inflammation et de cancer chez l'homme.

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