C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2656440
Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235- Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.
L'invention concerne des dimères polypeptidiques comprenant deux molécules gp130 solubles. Dans ladite invention, chacune desdites molécules est fusionnée ä un domaine Fc d'une protéine IgG1 et la région charnière du domaine Fc est modifiée, ce qui donne des propriétés avantageuses au dimère. Dans un mode de réalisation particulièrement préféré, la région charnière comprend le motif de séquence d'acides aminés Ala234-Glu235- Gly236-Ala237. En outre, une composition pharmaceutique contenant ledit dimère et diverses utilisations médicales sont décrites.
Seegert Dirk
Waetzig Georg H.
Conaris Research Institute Ag
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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