Improved stable topical ascorbic acid compositions

A - Human Necessities – 61 – K

Patent

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A61K 9/14 (2006.01) A61K 8/58 (2006.01) A61K 8/67 (2006.01) A61K 8/891 (2006.01) A61K 9/00 (2006.01) A61K 31/375 (2006.01) A61K 47/12 (2006.01) A61K 47/24 (2006.01) A61P 17/00 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2336799

An ascorbic acid (Vitamin C) composition in a nonaqueous or substantially anhydrous silicone vehicle has superior stability. Particulate ascorbic acid is substantially insoluble in the disclosed polyorganosiloxane vehicles, and the vehicle substantially excludes environmental oxygen. The ascorbic acid particles have surprisingly been found to have a high degree of bioavailability and effectiveness, for example in topical applications to reduce wrinkles and increase collagen growth and elasticity.

L'invention concerne une composition d'acide ascorbique (vitamine C) dans un support de silicium non aqueux ou sensiblement anhydre présentant une stabilité améliorée. L'acide ascorbique particulaire est sensiblement insoluble dans les supports de polyorganosiloxane faisant l'objet de l'invention et le support exclut sensiblement l'oxygène de l'environnement. Les expériences ont démontré, à notre grande surprise, que les particules d'acide ascorbique font preuve d'un degré élevé de biodisponibilité et d'efficacité, par exemple dans les applications topiques pour réduire les rides et augmenter la croissance du collagène et l'élasticité de la peau.

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