Improved stably tethered structures of defined compositions...

A - Human Necessities – 61 – K

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A61K 51/00 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2604034

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor. The first and second precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. The disclosed methods and compositions provide a simple, easy to purify way to obtain any binary compound attached to any monomeric compound, or any trinary compound.

L'invention concerne des procédés et des compositions destinées à des structures attachées de façon stable de compositions définies présentant diverses fonctions et/ou specificités de liaison. L'invention concerne notamment des structures attachées de façon stable comportant un homodimère d'un premier monomère, présentant un domaine de dimérisation et d'accouplage lié à un premier précurseur, et d'un deuxième monomère présentant un domaine d'ancrage attaché à un deuxième précurseur. Le premier et le deuxième précurseur peuvent se présenter sous la forme de toute molécule ou structure de type anticorps, fragments d'anticorps, analogues ou mimétiques d'anticorps, aptamères, peptides de liaison, fragments de protéines de liaison, ligands connus de protéines ou d'autres molécules, enzymes, étiquettes détectables, agents thérapeutiques, toxines, agents pharmaceutiques, cytokines, interleukines, interférons, radioisotopes, protéines, peptides, mimétiques de peptides, polynucléotides, ARNi, olisaccharides, substances polymères naturelles ou synthétiques, nanoparticules, points quantiques, composés organiques ou inorganiques etc. Les procédés et compositions selon l'invention constituent une manière simple, et aisément purifiable, de fabriquer tout composé binaire attaché à un composé monomère, ou tout composé ternaire.

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