Improved stannous oral compositions

Details Improved stannous oral compositions Improved stannous oral compositions

A - Human Necessities

61

K

A61K 8/90 (2006.01) A61K 8/19 (2006.01) A61K 8/21 (2006.01) A61K 8/24 (2006.01) A61K 8/365 (2006.01) A61K 8/73 (2006.01) A61K 8/81 (2006.01) A61Q 11/00 (2006.01)

Patent

CA 2389174

The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and/or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.

L'invention concerne des compositions buccales contenant une source d'ions étain, une source d'ions fluorure et un agent tensioactif minéral polymère se liant à l'étain. Ces compositions possèdent une efficacité thérapeutique adéquate, tout en limitant les effets secondaires d'astringence et de taches sur les dents. Elles permettent simultanément de diminuer ou d'empêcher le calcul supragingival. Elles peuvent être formulées en compositions à simple phase ou à double phase. L'invention concerne également un procédé servant à utiliser des compositions à teneur stanneuse permettant de limiter au maximum les effets secondaires des taches et de l'astringence et de lutter efficacement contre la formation de tartre par application d'une composition dentifrice stable contenant une quantité cliniquement efficace de fluorure d'étain et/ou de sels d'étain combinés à une source d'ions fluorure et à un agent tensioactif minéral polymère, de préférence, un polymère contenant phosphate ou phosphonate.

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