Improved stereoselective process for enalapril

Details Improved stereoselective process for enalapril Improved stereoselective process for enalapril

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2343193

The invention relates to an improved stereoselective heterogenous catalytic reductive amination between ethyl 2-oxo-4-phenylbutyrate and alanylproline using hydrogen, a catalyst and one or more additives to produce the ACE inhibitor, enalapril.

L'invention concerne un procédé stéréoselectif amélioré pour réaliser une amination de réduction catalytique hétérogène entre 2-oxo-4-phénylbutyrate d'éthyle et alanylproline. Le procédé met en oeuvre de l'hydrogène, un catalyseur et un ou plusieurs additifs pour produire l'enalapril, inhibiteur de l'enzyme de conversion (ACE).

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