Improved synthesis of...

Details Improved synthesis of... Improved synthesis of...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01)

Patent

CA 2685797

The present invention relates to an improved process for the preparation of (2S-cis)-2- (bromomethyl)-2-(4-chlorophenyl )-1,3-dioxolane-4-methanol methanesulfonate(ester), a key intermediate for the preparation of the apoB secretion/MTP inhibitor mitratapide.

La présente invention porte sur un procédé perfectionné pour la préparation de méthanesulfonate de (2S-cis)-2-(bromométhyl)-2-(4-chlorophényl)-1,3 dioxolane-4-méthanol(ester), un intermédiaire clé pour la préparation du mitratapide inhibiteur de la sécrétion de apoB/de MTP.

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