Improved synthesis of 2-substituted adenosines

Details Improved synthesis of 2-substituted adenosines Improved synthesis of 2-substituted adenosines

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01)

Patent

CA 2552591

A method of synthesis of a 2-substituted adenosine of formula I which comprises converting a compound of formula II to a compound of formula (I), wherein: R is C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy), a benzyloxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, Cl_6 alkyl, or Cl_6 alkoxy), or a benzoyl group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy); R' = H, or a protecting group.

L'invention concerne un procédé de synthèse d'une adénosine 2-substituée de formule (I) consistant à convertir un composé de formule (II) en un composé de formule (I), dans laquelle: R représente alcoxy en C 1-6 (droit ou ramifié), un groupe phénoxy (non substitué ou mono- ou di-substitué par halo, amino, CF3-, cyano, nitro, alkyle en C 1-6 ou alcoxy en C 1-6), un groupe benzyloxy (non substitué ou mono- ou di-substitué par halo, amino, CF3-, cyano, nitro, alkyle en C 1-6 ou alcoxy en C 1-6) ou un groupe benzoyle (non substitué ou mono- ou di-substitué par halo, amino, CF3-, cyano, nitro, alkyle en C 1-6 ou alcoxy en C 1-6); et R' = H ou un groupe protecteur.

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