Improved synthesis of oligosaccharides using activated...

Details Improved synthesis of oligosaccharides using activated... Improved synthesis of oligosaccharides using activated...

C - Chemistry, Metallurgy

12

P

C12P 19/18 (2006.01) C12N 9/10 (2006.01) C12P 19/30 (2006.01)

Patent

CA 2286456

Methods of forming oligosaccharides using activated glycosyl derivatives as donor sugars in the enzymatic synthesis of oligosaccharides are described. The enzymes used are typically glycosyl transferases. The donor sugars act as alternates to the naturally-occuring substrates and provide efficient synthesis routes to a variety of commercially important oligosaccharides. In addition, methods of forming nucleotide phosphate sugars in situ are disclosed.

Procédé servant à préparer des oligosaccharides au moyen de dérivés de glycosyl activés en tant que sucres donneurs dans la synthèse enzymatique d'oligosaccharides. Les enzymes utilisées sont généralement des glycosyl-transférases. Ces sucres donneurs servent d'alternatives aux substrats naturels et constituent des voies efficaces de synthèse vers une variété d'oligosaccharides présentant une importance commerciale. L'invention concerne, de plus, des procédés de préparation in-situ de sucres de phosphate de nucléotides.

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