Improved synthesis of polyanhydrides

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 327/26 (2006.01) A61K 47/48 (2006.01) C07C 67/14 (2006.01) C07C 69/88 (2006.01) C08G 67/04 (2006.01)

Patent

CA 2466039

The present invention provides a method for forming compounds of Formula HO-C(=O)R?1¿-X-R?2¿-X-R?1¿-C(=O)-O-H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R?1¿ is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R?2¿ is a linking group.

la présente invention concerne une méthode de fabrication de composés représentés par la formule HO-C(=O)R?1¿-X-R?2¿-X-R?1¿-C(=O)-O-H. Selon cette formule, le composé (I) peut être polymérisé et produire un polymère renfermant des composés actifs au plan thérapeutique. Dans les composés de l'invention, chaque R?1¿ représente un groupe fournissant le composé thérapeutiquement actif par hydrolyse du polymère; chaque X est indépendamment une liaison ester ou une liaison amide ; et R?2¿ est un groupe de liaison.

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