Improved synthesis of polymer bio-active conjugates

Details Improved synthesis of polymer bio-active conjugates Improved synthesis of polymer bio-active conjugates

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) C07K 17/08 (2006.01) C12N 9/50 (2006.01) C12N 11/08 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2150925

A process for the preparation of a conjugate between a polymer and a first substance having a biological activity mediated by a domain thereof, which process comprises: (a) contacting the first substance with a second substance which specifically binds to the said domain of the first substance (b); conjugating a polymer to the first substance having the second substance bound thereof; and (c) freeing the second substance from the first substance having the polymer conjugated thereto. Conjugates between a polymer and an antibody against TNF-.alpha..

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