Improved targeted hysteresis hyperthermia as a method for...

A - Human Necessities – 61 – K

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A61K 41/00 (2006.01) A61K 47/02 (2006.01) A61K 47/48 (2006.01) A61N 1/40 (2006.01) A61N 2/04 (2006.01) H01F 1/28 (2006.01) H05B 6/62 (2006.01)

Patent

CA 2252199

-34- The present invention provides an improved method for treatment of diseased tissue, which comprises the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5 x 10-8 J.m./A.g, when rotational magnetic field conditions are equal to or less than about 5 x 10 8 A/m.s; (ii) delivering the magnetic material to a patient's diseased tissue; and (iii) exposing the magnetic material to a rotational magnetic field with a frequency of greater than about 10kHz and a field strength selected such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5 x 10 7 A/s to generate hysteresis heat in the diseased tissue.

La présente invention porte sur une méthode améliorée de traitement d'un tissu malade, laquelle comporte les étapes suivantes: (i) choisir au moins un matériau magnétique qui a une efficacité de chauffage magnétique d'au moins environ 4,5 x 10-8 J.m/A.g, quand les conditions de champ magnétique rotationnel sont égales ou inférieures à environ 5 x 10 8 A/m.s; (ii) appliquer le matériau magnétique au tissu malade d'un patient; et (iii) exposer le matériau magnétique à un champ magnétique rotationnel avec une fréquence supérieure à environ 10 kHz et une intensité de champ choisie de manière que le produit de l'intensité de champ, de la fréquence et du rayon de la zone exposée soit inférieur à environ 7,5 x 10 7 A/s de manière à générer une chaleur par hystérésis dans le tissu malade.

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