Improved therapeutic agents

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 19/09 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2227533

This invention relates to now nucleoside derivatives of formula (I); wherein R1 and R2 are independently selected from hydrogen, elaidoyl, oleoyl, stearoyl, eicosenoyl (cis or trans) and eicosanoyl, with the provisos that R1 and R2 cannot both be hydrogen, oleoyl or stearoyl, R1 cannot be hydrogen when R2 is oleoyl or stearoyl, and R2 cannot be hydrogen when R1 is elaidoyl, oleoyl or stearoyl. Further, the invention relates to the use of the nucleoside derivatives of formula (I) wehrein R1 and R2 are independently selected from hydrogen, and C18- and C20-saturated and mono-unsaturated acyl groups, with the provisos that R1 and R2 cannot both be hydrogen, in the manufacture of a pharmaceutical preparation for the treatment of tumours.

L'invention porte sur de nouveaux dérivés de nucléosides de formule (I) dans laquelle R1 et R2 sont choisis indépendamment parmi hydrogène, élaïdoyle, oléoyle, stéaroyle, éicosénoyle (cis ou trans) et éicosanoyle, sous réserve que R1 et R2 ne puissent être tous deux hydrogène, oléoyle ou stéaroyle, que R1 ne puisse être hydrogène lorsque R2 est oléoyle ou stéaroyle, et que R2 ne puisse être hydrogène lorsque R1 est élaïdoyle, oléoyle ou stéaroyle. L'invention porte également sur l'emploi de dérivés de nucléosides de formule (I) dans laquelle R1 et R2 sont choisis indépendamment parmi hydrogène et des groupes acyle C18- et C20- saturés et mono-insaturés, sous réserve que R1 et R2 ne puissent être tous deux hydrogène. Ces dérivés sont utilisés dans la fabrication de préparations pharmaceutiques pour le traitement de tumeurs.

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