Improved therapeutic compositions comprising...

Details Improved therapeutic compositions comprising... Improved therapeutic compositions comprising...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 47/18 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2210390

Improved therapeutic compositions having enhanced anti-microbial activity comprising a bactericidal/permeability-increasing (BPI) protein product and an bactericidal-activity enhancing polyoxyethylene block copolymer surfactant (poloxamer surfactant) or a bacterial and fungal growth-inhibiting enhancing poloxamer surfactant, optionally with EDTA, and methods for treating bacterial infection by administering such compositions, alone or concurrently with antibiotics.

L'invention concerne des compositions thérapeutiques améliorées présentant une activité antimicrobienne accrue. Ces compositions comprennent une protéine augmentant le pouvoir bactéricide/perméabilisant et un agent tensioactif copolymère bloc de polyoxyéthylène renforçant le pouvoir bactéricide (agent tensioactif de poloxamère) ou un agent tensioactif de poloxamère augmentant le pouvoir d'inhibition de la croissance fongique et bactérienne, et éventuellement de l'acide éthylènediaminetétraacétique. L'invention a aussi pour objet des procédés pour traiter des infections bactériennes par administration de ce type de compositions, seules ou en association avec des antibiotiques.

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