Improved thyroid hormone formulations

Details Improved thyroid hormone formulations Improved thyroid hormone formulations

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 9/20 (2006.01) A61K 31/198 (2006.01)

Patent

CA 2415080

A method is disclosed for formulating a solid dosage of thyroid hormone, while avoiding instability caused by interaction of the active ingredient with excipients. The thyroid hormone may be levothyroxine sodium or triiodothyronine. The method comprises depositing the active ingredient, preferably electrostatically, as a dry powder substantially free of excipients, onto a pharmaceutically acceptable polymer substrate. Solid pharmaceutical dosage forms also are disclosed.

L'invention concerne un procédé de formulation d'une forme galénique solide d'hormone thyroïdienne, qui permet d'éviter l'instabilité provoquée par l'interaction du principe actif avec les excipients. Cette hormone thyroïdienne peut être du sodium de lévothyroxine ou une triiodothyronine. Le procédé consiste à déposer le principe actif, de préférence de manière électrostatique, en tant que poudre sèche sensiblement dépourvue d'excipients, sur un substrat polymère, acceptable sur le plan pharmacologique. L'invention concerne également des formes galéniques pharmaceutiques.

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