A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/22 (2006.01)
Patent
CA 2631948
TSHR agonists that are substantially desialylated are described for treating metabolic syndrome and obesity and for inducing lipolysis. The TSHR polypeptide agonists are useful for treatment of hallmarks of metabolic syndrome: obesity, insulin resistance, hyperlipidemia, and liver steatosis, without producing a hyperthyroid state in treated individuals.
La présente invention concerne des agonistes TSHR substantiellement désialylés pour traiter un syndrome et une obésité métabolique et pour induire une lipolyse. Les agonistes de polypeptides de TSHR sont utiles pour traiter les indications du syndrome métabolique, à savoir : l~obésité, la résistance à l~insuline, l~hyperlipidémie et la stéatose du foie, sans produire d~état hyperthyroïdien chez les individus traités.
Borden Ladner Gervais Llp
Kelly James D.
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