A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 18/02 (2006.01)
Patent
CA 2248856
Cell and tissue destruction by cryoablation is enhanced by the perfusion of the cells with thermal hysteresis proteins prior to the cryogenic freezing. The effect of the proteins is to promote the growth of spicular ice crystals in the intracellular fluid which destroy the cell by piercing the cell membrane. This decreases the incidence of cell preservation by freezing, thereby permitting a more uniform and controllable destruction of undesirable tissue by the cryoablation technique.
On a amélioré la destruction de cellules et de tissus par cryoablation par la perfusion de protéines d'hystérésis thermique dans les cellules avant la congélation cryogénique. L'effet des protéines est de stimuler la croissance de crystaux de glace spiculaires dans le fluide intracellulaire, lesquels détruisent la cellule en perçant la membrane cellulaire. Ceci réduit l'incidence de la conservation cellulaire par congélation, permettant ainsi d'obtenir une destruction plus uniforme et régulable des tissus indésirables par la technique de cryoablation.
Koushafar Amir-Homayoon
Rubinsky Boris
Fetherstonhaugh & Co.
The Regents Of The University Of California
LandOfFree
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