Improved topical medicaments and methods for photodynamic...

Details Improved topical medicaments and methods for photodynamic... Improved topical medicaments and methods for photodynamic...

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 9/12 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 47/48 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 311/82 (2006.01) C07D 311/88 (2006.01) A61B 18/20 (2006.01) A61N 5/06 (2006.01)

Patent

CA 2380805

New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

L'invention concerne de nouveaux médicaments topiques et photodynamiques ainsi que certaines utilisations médicales de ces médicaments photodynamiques pour le traitement de tissus humains ou animaux. Un composant actif primaire de ces médicaments est un xanthène halogéné. Ces xanthènes halogénés constituent une famille de puissants photosensibilisants qui sont photoactivés par éclairage du site de traitement au moyen de longueurs d'ondes visibles lumineuses. Dans certains modes de réalisation, ces médicaments servent à traiter différentes maladies touchant la peau et les organes connexes ; la bouche et le système digestif; les voies urinaires, génitales et les organes connexes ; les voies respiratoires et les organes connexes; plusieurs autres surfaces tissulaires internes ou externes, telles que les surfaces tissulaires exposées lors d'une intervention chirurgicale ; et pour le traitement de différentes maladies liées à une infection microbienne ou parasitaire. Dans un autre mode de réalisation préféré, ces médicaments sont produits avec différentes formulations, notamment des excipients liquides, semi-solides ou sous forme d'aérosol.

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