Improved transdermal contraceptive delivery system and process

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/567 (2006.01) A61K 9/70 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61P 15/18 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2391430

A transdermal contraceptive delivery system (TCDS) for fertility control in women is described comprising a backing layer, an adjoining layer of a solid absorption adhesive polymer matrix in which minimum effective daily doses of an estrogen and a progestin are dispersed and released for transdermal absorption. Presently preferred is use of the synthetic estrogen, ethinyl estradiol, and the synthetic progestin, levonorgestrel. Along with these two steroidal contraceptive agents, a combination of several chemical skin permeation enhancing agents, including capric acid, blended at specific weight ratios, ranging from 2.0:1:1:0.8 to 6:1:1:0.8 are homogeneously dispersed in the adhesive polymer matrix. The invention also provides a method of fertility control utilizing the transdermal contraceptive delivery system.

L'invention concerne un système d'administration de contraception transdermique (TCDS) utilisé dans une méthode de contraception pour les femmes, comprenant une couche de soutien et une couche adjacente faite d'une matrice polymère solide absorbante adhésive dans laquelle sont dispersées et libérées des doses quotidiennes minimales efficaces d'oestrogène et de progestine pour une absorption transdermique. Dans un mode de réalisation préféré, on utilise une oestrogène de synthèse, l'éthinyloestradiol, et une progestine de synthèse, le lévonorgestrel. En plus de ces deux agents contraceptifs stéroïdiques, plusieurs agents chimiques combinés favorisant la perméabilité de la peau, y compris l'acide caprique, mélangés selon des rapports de poids spécifiques variant de 2,0:1:1:0,8 à 6:1:1:0,8, sont dispersés de façon homogène dans la matrice polymère adhésive. L'invention concerne également un méthode de contraception dans laquelle est utilisé le système d'administration de contraception transdermique.

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