Improved transdermal delivery system

Details Improved transdermal delivery system Improved transdermal delivery system

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/38 (2006.01)

Patent

CA 2490573

An improved Transdermal Delivery System (TDS) comprising a backing layer inert to the components of the matrix, a self-adhesive matrix containing an amine- functional drug and a protective foil or sheet to be removed priorto use, characterized in that the self-adhesive matrix consists of a solid or semi- solid semi-permeable polymer (1)wherein an amine functional drug in its free base form has been incorporated, (2) which is saturated with the aminefunctional drug and contains said drug as a multitude of microreservoirs within the matrix, (3) which is highly permeable for the free base of the amine functional drug, (4) which is impermeable for the protonated form of the amine functional drug, (5) wherein the maximum diameter of the microreservoirs is less than the thickness of the matrix. is provided. Said TDS provides for enhanced flux of the amine functional drug across the TDS/skin interface.

L'invention concerne un système d'administration transdermique (TDS) amélioré comprenant une couche d'appui insensible aux composants de la matrice, une matrice auto-adhésive contenant un médicament à fonctionnalité amine et un film ou une feuille de protection à enlever avant emploi. Ledit système se caractérise en ce que la matrice auto-adhésive est constituée d'un polymère semi-perméable solide ou semi-solide, (1) dans lequel on a incorporé un médicament à fonctionnalité amine sous sa forme de base libre, (2) qui est saturé du médicament à fonctionnalité amine et contient ledit médicament en de multiples microréservoirs dans la matrice, (3) qui est hautement perméable pour la base libre du médicament à fonctionnalité amine, (4) qui est imperméable au médicament à fonctionnalité amine sous sa forme protonée, (5) le diamètre maximal des microréservoirs étant inférieur à l'épaisseur de la matrice. Ledit TDS permet d'assurer un flux amélioré du médicament à fonctionnalité amine à travers l'interface TDS/peau.

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