Improved transdermal delivery system for the administration...

Details Improved transdermal delivery system for the administration... Improved transdermal delivery system for the administration...

A - Human Necessities

61

K

A61K 31/381 (2006.01) A61K 9/70 (2006.01) A61K 31/38 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2491366

An improved Transdermal Delivery System (TDS) comprising a backing layer inert to the components of the matrix, a self-adhesive matrix containing rotigotine and a protective foil or sheet to be removed prior to use, characterized in that the self-adhesive matrix consists of a solid or semi-solid semi-permeable polymer (1) wherein rotigotine in its free base form has been incorporated, (2) which is saturated with rotigotine and contains said rotigotine as a multitude of microreservoirs within the matrix, (3) which is highly permeable for the free base of rotigotine, (4) which is impermeable for the protonated form of rotigotine, (5) wherein the maximum diameter of the microreservoirs is less than the thickness of the matrix. is provided. Said TDS provides for enhanced flux of rotigotine across the TDS/skin interface.

L'invention concerne un système d'administration transdermique (TDS) amélioré comprenant une couche d'appui insensible aux composants de la matrice, une matrice auto-adhésive contenant de la rotigotine et un film ou une feuille de protection à enlever avant emploi. Ledit système se caractérise en ce que la matrice auto-adhésive est constituée d'un polymère semi-perméable solide ou semi-solide (1) dans lequel la rotigotine a été incorporée sous sa forme de base libre, (2) qui est saturé de la rotigotine et contient ladite rotigotine en de multiples microréservoirs dans la matrice, (3) qui est hautement perméable pour la base libre de la rotigotine, (4) qui est imperméable à la rotigotine sous sa forme protonée, (5) le diamètre maximal des microréservoirs est inférieur à l'épaisseur de la matrice. Ledit TDS permet d'assurer un flux amélioré de la rotigotine à travers l'interface TDS/peau.

Affiliated with

Also associated with

Rating

Improved transdermal delivery system for the administration... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Improved transdermal delivery system for the administration..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Improved transdermal delivery system for the administration... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1808011