Improved treatment and prophylaxis

Details Improved treatment and prophylaxis Improved treatment and prophylaxis

A - Human Necessities

61

K

A61K 38/02 (2006.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 31/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2746551

This invention discloses the use of an E-selectin antagonist and a mobilizer of hematopoietic stem cells or progenitor cells in methods and compositions for treating or preventing immunocompromised conditions resulting from medical treatment. The present invention is particular relevant for prophylaxis and/or treatment of hematopoeitic disorders including neutropenia, agranulocytosis, anemia and thrombocytopenia in individuals receiving or proposed to receive treatments that target rapidly dividing cells or that disrupt the cell cycle or cell division.

L'invention concerne l'utilisation d'un antagoniste de la sélectine E et d'un mobilisateur de cellules souches hématopoïétiques ou de cellules progénitrices dans le cadre de méthodes et pour des compositions destinées à traiter ou à prévenir des états immunocompromis dus à des traitements médicaux. Cette invention convient particulièrement pour la prophylaxie et/ou le traitement de troubles hématopoïétiques, dont la neutropénie, l'agranulocytose, l'anémie et la thrombocytopénie, chez des individus recevant ou censés recevoir des traitements qui ciblent des cellules à division rapide ou qui bouleversent le cycle cellulaire ou la division cellulaire.

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