C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) C07K 14/02 (2006.01) C12N 7/04 (2006.01) C12N 15/33 (2006.01) C12N 15/51 (2006.01)
Patent
CA 2417719
Isolated polynucleotides comprising a HBsAg-S coding sequence that is adapted to receive an insert coding sequence, within a part of the HBsAg-S coding sequence that encodes an exposed site within the external loop of HBsAg-S, and still encode a HBsAg-S that is able to assemble into a VLP. Proteins encoded by the polynucleotides, recombinant VLPs and various uses thereof are also described.
L'invention concerne des polynucléotides isolés comprenant une séquence codante de AgHB-S pouvant recevoir une séquence codante introduite, dans une portion de la séquence codante de AgHBS codant pour un site exposé à l'intérieur de la boucle extérieure de AgHBS, et codant également pour un AgHBS pouvant se regrouper en une particule de type virus . L'invention concerne également des protéines codées par les polynucléotides, des particules de type virus de recombinaison, ainsi que diverses utilisations de ceux-ci.
James Gowans Eric
Macnaughton Thomas Bernard
Netter Hans Jurgen
Monash University
Sim & Mcburney
The Crown In The Right Of The Queensland Department Of Health
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