Improved yeast strain for production of four carbon alcohols

Details Improved yeast strain for production of four carbon alcohols Improved yeast strain for production of four carbon alcohols

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C12P 7/16 (2006.01)

Patent

CA 2724304

Yeast cells with a reduced general control response to amino acid starvation were found to have increased tolerance to butanol in the growth medium. The reduced response was engineered by genetic modification of a gene involved in the response, a GCN gene, to eliminate activity of the encoded protein. Yeast strains with an engineered butanol biosynthetic pathway and a genetic modification in a gene involved in the general control response to amino acid starvation, which have increased butanol tolerance, are useful for production of butanol.

Selon linvention, des cellules de levure qui présentent une réponse générale de contrôle réduite à la privation dacides aminés présentent une tolérance accrue au butanol en milieu de croissance. La réponse réduite est produite par modification génétique dun gène impliqué dans la réponse, un gène GCN, afin déliminer lactivité de la protéine codée. Les souches de levure avec une voie biosynthétique de butanol modifiée et une modification génétique dun gène impliqué dans la réponse générale de contrôle à la privation dacides aminés, qui présentent une tolérance au butanol accrue, sont utiles pour la production de butanol.

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