A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 31/445 (2006.01) A61K 38/09 (2006.01) A61K 39/39 (2006.01) A61P 5/02 (2006.01) A61P 5/24 (2006.01) A61P 37/04 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2370296
The present invention provides a method of modifying the T-cell population makeup or increasing the number of T-cells in a subject having depressed or abnormal T-cell population or function, the method comprising disrupting sex steroid signalling to the thymus in the subject. The invention can be used to treat a subject suffering from a wide array of diseases, for example, cancer, HIV infection, autoimmunity and hypersensitivity. In addition, the present invention provides methods for enhancing an immune response to an antigen, treating an autoimmune disease, and decreasing a host-vs-graft reaction in a transplantation donor.
L'invention concerne une technique permettant de modifier la composition de la population de lymphocytes T ou d'augmenter le nombre de ceux-ci chez un sujet présentant une population ou une fonction de lymphocyte T anormale ou réduite, cette technique consistant à interrompre le signalement d'un stéroide sexuel au thymus d'un sujet. L'invention permet de traiter un sujet qui souffre d'une grande variété de maladies, par exemple, du cancer, d'une infection due au VIH, d'auto-immunité et d'hypersensibilité. Elle concerne, en outre, des techniques qui permettent d'améliorer la réponse immunitaire à un antigène, de traiter une maladie auto-immune, et de réduire une réaction de l'hôte contre le greffon dans une transplantation.
Monash University
Norwood Immunology Ltd
Smart & Biggar
LandOfFree
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