Improvement of the bioavailability of active substances...

Details Improvement of the bioavailability of active substances... Improvement of the bioavailability of active substances...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2658434

The invention relates to the use of N,N'-dihydroxyamidine (I), N,N'-dihydroxyamidine ether (II), N,N'-dihydroxyamidine diether (III), N,N'-dihydroxyamidine ester (IV), N,N'-dihydroxyamidine diester (V) or 4-hydroxy-1,2,4-oxadiazoline (VI) of the formulae cited above, wherein R represents hydrogen, an alkyl and/or aryl radical, as a substitute for an amidine function of a medicament for improving the bioavailability of the medicament.

L'invention concerne l'utilisation de N,N'-dihydroxyamidine (I), d'éther de N,N'-dihydroxyamidine (II), de diéther de N,N'-dihydroxyamidine (III), d'ester de N,N'-dihydroxyamidine (IV), de diester de N,N'-dihydroxyamidine (V) ou de 4-hydroxy-1,2,4-oxadiazoline (VI), ayant les formules indiquées où R représente hydrogène, un reste alkyle et/ou un reste aryle, en remplacement d'une fonction amidine d'une substance médicamenteuse afin d'améliorer la biodisponibilité de cette substance médicamenteuse.

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