Improvement of tolerance to a xenograft

Details Improvement of tolerance to a xenograft Improvement of tolerance to a xenograft

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2353960

The invention hereindescribed relates to a method to improve the tolerance of a mammal, preferably a human, to a xenograft through immunisation of the recipient mammal with an immunogen comprising both a B cell epitope derived from porcine polypeptides and T cell epitope. The invention also encompasses immunogenic compositions comprising said immunogens and methods to monitor the status of the xenograft.

L'invention concerne un procédé permettant d'améliorer la tolérance d'un mammifère, de préférence un humain, à une xénogreffe par l'intermédiaire de l'immunisation du mammifère receveur au moyen d'un immunogène comprenant un épitope de lymphocytes B dérivé de polypeptides porcins et un épitope de lymphocytes T. L'invention concerne également des compositions immunogènes comprenant lesdits immunogènes ainsi que des procédés permettant de surveiller la xénogreffe.

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