A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/485 (2006.01) A61K 9/08 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2678582
A composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the dermis or mucosa, comprises buprenorphine and an amount of naloxone such that the ratio by weight of buprenorphine to naloxone delivered to or reaching the plasma of a patient is in the range of from 7.5:1 to 12.4:1. The analgesic action of the buprenorphine is potentiated by the low dose of naloxone, which also serves to reduce the likelihood of abuse of the composition by drug addicts. Also provided are a method of treatment of pain and the use of naloxone and buprenorphine for the manufacture of a medicament.
L'invention porte sur une composition, sous forme posologique parentérale ou sous une forme posologique apte à être administrée à travers la peau ou les muqueuses, qui comprend de la buprénorphine et de la naloxone dans une quantité telle que le rapport en poids de la buprénorphine et de la naloxone administré à un patient ou atteint dans le plasma du patient est compris entre 7,5:1 et 12,4:1. L'action analgésique de la buprénorphine est potentialisée par la faible dose de naloxone, qui permet également de réduire le risque de dépendance à la composition chez les toxicodépendants. L'invention concerne également un procédé de traitement de la douleur et l'utilisation de naloxone et de buprénorphine dans la fabrication d'un médicament.
Chapleo Christopher Bourne
Hyde Neil
Fetherstonhaugh & Co.
Reckitt Benckiser Healthcare (uk) Limited
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