Improvements in benzodiazepine treatment by cholinesterase...

Details Improvements in benzodiazepine treatment by cholinesterase... Improvements in benzodiazepine treatment by cholinesterase...

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/5513 (2006.01)

Patent

CA 2468449

The use of a pharmaceutically acceptable cholinesterase inhibitor or a prodrug therefor for counteracting the sedative, hypnotic or respiratory depressive effects of benzodiazepines, substantially without interfering with the anxiolytic, antipsychotic, anticonvulsant, and muscle relaxant activity of benzodiazepines, especially the benzodiazepines used for treatment of diseases where the sedative, hypnotic or respiratory depressive effects are undesirable, such as diseases selected from the group consisting of anxiety, anxiety neurosis, anxiety reactions, panic reactions, schizophrenia, affective or schizoaffective type schizophrenia, borderline psychosis, agitating endogene depressions, hyperactivity in children, and muscle spasms. The acetyl cholinesterase is preferably ones that acts substantially selectivity at nicotinic receptor sites, and which has selectively for acetyl cholinesterase opposed to butyryl cholinesterase, e.g. galanthamine or a galanthamine derivative.

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