Improvements in crystallization of an intermediate for...

Details Improvements in crystallization of an intermediate for... Improvements in crystallization of an intermediate for...

C - Chemistry, Metallurgy

07

C

C07C 231/22 (2006.01) C07C 231/12 (2006.01) C07C 237/46 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2710102

This invention relates generally to the crystallization process of 5-amino-N, N'- bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide ("Compound B"), an iodinated intermediate in the preparation of non-ionic X-ray contrast agents. The instant process utilizes a nanofiltration system to pass through low molecular weight salt, thereby reducing the solubility of Compound B in the retentate. This process increases supersaturation of the mother liquor and improves crystal growth in the crystallization following the initial one. The process of the present invention is useful in increasing the overall crystallization yield of Compound B in an industrial manufacturing process.

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