Improvements in ms/ms methods for a quadrupole/time of...

Details Improvements in ms/ms methods for a quadrupole/time of... Improvements in ms/ms methods for a quadrupole/time of...

H - Electricity

01

J

H01J 49/40 (2006.01)

Patent

CA 2255122

There is provided a method of effecting mass analysis on an ion stream, the method comprising passing the ion stream through a first mass resolving spectrometer, to select parent ions having a first desired mass -to--charge ratio. The parent ions are them subject to collision-induced dissociation (CID) to generate fragment ions, and the fragment ions and any remaining parent ions are trapped; the CID and trapping can be carried out together in a linear ion trap. Periodically pulses of the trapped ions are released into a time of flight (TOF) instrument to determine the mass -to--charge ratio of the ions. The delay between the release of the pulses and the initiation of the push-pull pulses of the TOF instrument are adjusted to maximize the duty cycle efficiency and hence the sensitivity for a selected ions with a desired mass-to-charge ratio. This technique can be used to optimize the performance for a parent ion scan, and MRM scan or a neutral loss scan.

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